Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. Tahtouh T, Elkins JM, Filippakopoulos P, Soundararajan M, Burgy G, Durieu E, Cochet C, Schmid RS, Lo DC, Delhommel F, Oberholzer AE, Pearl LH, Carreaux F, Bazureau JP, Knapp S, Meijer L. J Med Chem. 2012 Nov 8;55(21):9312-30. PMID: 22998443

Multicomponent venom of the spider Cupiennius salei: a bioanalytical investigation applying different strategies. Trachsel C, Siegemund D, Kämpfer U, Kopp LS, Bühr C, Grossmann J, Lüthi C, Cunningham M, Nentwig W, Kuhn-Nentwig L, Schürch S, Schaller J. FEBS J. 2012 Aug;279(15):2683-94. doi: 10.1111/j.1742-4658.2012.08650.x. Epub 2012 Jun 18. PMID: 22672445


Structural and biochemical characterization of native and recombinant single insulin-like growth factor-binding domain protein (SIBD-1) from the Central American hunting spider Cupiennius salei (Ctenidae). Trachsel C, Widmer C, Kämpfer U, Bühr C, Baumann T, Kuhn-Nentwig L, Schürch S, Schaller J, Baumann U. Proteins. 2012 Aug;80(9):2323-9. doi: 10.1002/prot.24119. Epub 2012 Jun 18. PMID: 22622866


A venom-derived neurotoxin, CsTx-1, from the spider Cupiennius salei exhibits cytolytic activities. Kuhn-Nentwig L, Fedorova IM, Lüscher BP, Kopp LS, Trachsel C, Schaller J, Vu XL, Seebeck T, Streitberger K, Nentwig W, Sigel E, Magazanik LG. J Biol Chem. 2012 Jul 20;287(30):25640-9. Epub 2012 May 21. PMID: 22613721

2011

Phosphoenolpyruvate: sugar phosphotransferase system from the hyperthermophilic Thermoanaerobacter tengcongensis. Navdaeva V, Zurbriggen A, Waltersperger S, Schneider P, Oberholzer AE, Bähler P, Bächler C, Grieder A, Baumann U, Erni B. Biochemistry. 2011 Feb 22;50(7):1184-93. Epub 2011 Jan 20. PMID: 21250658

2010

Crystal structure of archaemetzincin AmzA from Methanopyrus kandleri at 1.5 A resolution. Waltersperger S, Widmer C, Wang M, Baumann U. Proteins. 2010 Sep;78(12):2720-3. PMID: 2059709

Structure and function of CinD (YtjD) of Lactococcus lactis, a copper-induced nitroreductase involved in defense against oxidative stress. Mermod M, Mourlane F, Waltersperger S, Oberholzer AE, Baumann U, Solioz M. J Bacteriol. 2010 Aug;192(16):4172-80. Epub 2010 Jun 18. PMID: 20562311

2009

Crystal structure of enzyme I of the phosphoenolpyruvate sugar phosphotransferase system in the dephosphorylated state. Oberholzer AE, Schneider P, Siebold C, Baumann U, Erni B. J Biol Chem. 2009 Nov 27;284(48):33169-76. Epub 2009 Sep 28. PMID: 19801641

The crystal structure of caspase-6, a selective effector of axonal degeneration. Baumgartner R, Meder G, Briand C, Decock A, D'arcy A, Hassiepen U, Morse R, Renatus M. Biochem J. 2009 Oct 12;423(3):429-39. PMID: 19694615

Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site. Oberholzer AE, Bumann M, Hege T, Russo S, Baumann U. Biol Chem. 2009 Sep;390(9):875-81. PMID: 19558324

Elucidation of the disulfide bridge pattern of the recombinant human growth and differentiation factor 5 dimer and the interchain Cys/Ala mutant monomer. Trachsel C, Kämpfer U, Bechtold R, Schaller J, Schürch S. Anal Biochem. 2009 Jul 15;390(2):103-8. PMID: 19393216

Spider Venom and Hemolymph-Derived Cytolytic and Antimicrobial Peptides. Kuhn-Nentwig L., Trachsel C. and Nentwig W. (2009) In Howl J. and Jones S. (Eds.), Bioactive Peptides (pp. 447-464), CRC Press Boca Raton, USA. ISBN: 9781420061147

Classical swine fever virus can remain virulent after specific elimination of the interferon regulatory factor 3-degrading function of Npro. Ruggli N, Summerfield A, Fiebach AR, Guzylack-Piriou L, Bauhofer O, Lamm CG, Waltersperger S, Matsuno K, Liu L, Gerber M, Choi KH, Hofmann MA, Sakoda Y, Tratschin JD. J Virol. 2009 Jan;83(2):817-29. Epub 2008 Nov 5. PMID: 18987150

2008

Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions. Schütz P, Bumann M, Oberholzer AE, Bieniossek C, Trachsel H, Altmann M, Baumann U. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9564-9. Epub 2008 Jul 7. PMID: 18606994

Human Blood Plasma Proteins: Structure and Function. Schaller J., Gerber S., Kämpfer U., Lejon S. and Trachsel C. (2008) John Wiley&Sons Ltd. Chinchester, England. ISBN: 9780470016749

2006

Crystal structure of the nucleotide-binding subunit DhaL of the Escherichia coli dihydroxyacetone kinase. Oberholzer AE, Schneider P, Baumann U, Erni B. J Mol Biol. 2006 Jun 9;359(3):539-45. Epub 2006 Apr 18. PMID: 16647083

Small substrate, big surprise: fold, function and phylogeny of dihydroxyacetone kinases. Erni B, Siebold C, Christen S, Srinivas A, Oberholzer A, Baumann U. Cell Mol Life Sci. 2006 Apr;63(7-8):890-900. Review. PMID: 16505971

2005

Crystal structure of the phosphoenolpyruvate-binding enzyme I-domain from the Thermoanaerobacter tengcongensis PEP: sugar phosphotransferase system (PTS). Oberholzer AE, Bumann M, Schneider P, Bächler C, Siebold C, Baumann U, Erni B. J Mol Biol. 2005 Feb 18;346(2):521-32. Epub 2004 Dec 22. PMID: 15670601

2004

Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits. Bumann M, Djafarzadeh S, Oberholzer AE, Bigler P, Altmann M, Trachsel H, Baumann U. J Biol Chem. 2004 Aug 27;279(35):37087-94. Epub 2004 Jun 23. PMID: 15215245